Cannabinol is an oxidative derivative of cannabis that exhibits high affinity for peripheral CB2 receptors and gentle partial agonism at central CB1 receptors. In clinical and pre-clinical observations, CBN assists in calming autonomic vigilance in the locus coeruleus, supporting smooth delta-wave slow-wave sleep transitions when combined with CBD.
Primary Receptors: CB1 (Partial), CB2, TRPA1
Featuring a 3-carbon propyl side chain instead of the standard 5-carbon pentyl chain, THCV functions as a neutral antagonist at the CB1 receptor at low-to-moderate doses. It delivers clean daytime mental clarity, executive focus, and healthy glycemic tone without any intoxicating psychoactivity.
Primary Receptors: CB1 (Neutral Antagonist), 5-HT1A
Known as the foundational "mother cannabinoid," CBG interacts directly with alpha-2 adrenergic receptors and 5-HT1A serotonin receptors. It supports steady cognitive stamina, neurological resilience, and digestive homeostasis during demanding mental and physical tasks.
Primary Receptors: α2-Adrenergic, 5-HT1A, CB2
Cannabichromene is a potent agonist of Transient Receptor Potential Ankyrin 1 (TRPA1) ion channels. When delivered alongside high-polyphenol olive oil, CBC promotes physical ease in muscles and joints following athletic exertion or daily physical strain.
Primary Receptors: TRPA1, TRPV1, CB2